Modeling the human skin barrier—Towards a better understanding of dermal absorption
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چکیده
منابع مشابه
I-34: NRY Haplotype Analysis: towards A Better Understanding of The Genetic Basis of Spermatogenic Failure
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Skin constitutes an excellent barrier for the transdermal delivery of hydrophilic or high molecular weight drugs. Low efficacy demonstrated in clinical trials for some topical drugs is mainly due to low skin penetration ability related to the efficient barrier properties of stratum corneum (SC). Transdermal delivery of molecules in the skin is limited by the full epidermis, not just stratum cor...
متن کاملUse of Microneedle Device to Enhance Dermal Absorption: Study on Ex Vivo Human Skin
Skin constitutes an excellent barrier for the transdermal delivery of hydrophilic or high molecular weight drugs. Low efficacy demonstrated in clinical trials for some topical drugs is mainly due to low skin penetration ability related to the efficient barrier properties of stratum corneum (SC). Transdermal delivery of molecules in the skin is limited by the full epidermis, not just stratum cor...
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OBJECTIVES To determine the kinetics of elimination of urinary dialkylphosphate metabolites after oral and dermally applied doses of the organophosphate pesticide chlorpyrifos to human volunteers and to determine whether these doses affected plasma and erythrocyte cholinesterase activity. METHOD Five volunteers ingested 1 mg (2852 nmol) of chlorpyrifos. Blood samples were taken over 24 hours ...
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Geer et al. (2004) provided an interesting comparison between passive dosimetry measures and biomonitoring for chlorpyrifos (CP) exposure in pesticide workers. However, they made a questionable assumption of a 3% dermal absorption factor (DAF) for CP, stating: ‘[The] study by Nolan et al. (1984), supports the use of a 3% DAF, the Environmental Protection Agency (EPA) accepted value, whereas Kri...
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ژورنال
عنوان ژورنال: Advanced Drug Delivery Reviews
سال: 2013
ISSN: 0169-409X
DOI: 10.1016/j.addr.2012.12.002